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KMID : 1009020190170020318
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Clinical Psychopharmacology and Neuroscience
2019 Volume.17 No. 2 p.318 ~ p.322
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Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naive Patients with Major Depression: A Study in the “Real World” Clinical Practice
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De Berardis Domenico
Olivieri Luigi
Rapini Gabriella
Di Natale Serena
Serroni Nicola
Fornaro Michele
Orsolini Laura
Valchera Alessandro
Carano Alessandro
Vellante Federica
Varasano Paola Annunziata
Pressanti Gabriella Lucidi
Serafini Gianluca
Pompili Maurizio
Martinotti Giovanni
Di Giannantonio Massimo
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Abstract
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Objective: This study was performed to elucidate relationships between alexithymia, suicide ideation and homocysteine levels in drug-naive outpatients with major depressive disorder (MDD).
Methods: Sixty seven outpatients with MDD with melancholic features were evaluated by the means of the Hamilton Depression Rating Scale, the Toronto Alexithymia Scale (TAS?20), the Scale of Suicide Ideation, and homocysteine levels.
Results: Alexithymic subjects showed higher scores on all scales and higher homocysteine levels. Regression analysis shown higher homocysteine levels and TAS-20’ “Difficulty in Describing Feelings” dimension, in turn being associated with higher suicide ideation.
Conclusion: In conclusion, alexithymic MDD outpatients may characterize for homocysteine dysregulation that may be linked to suicide ideation, regardless depression’ severity. However, study limitations are discussed and must be considered.
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KEYWORD
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Affective symptoms, Alexithymia, Depression, Suicidal ideation, Homocysteine
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